Endocrine Abstracts

Background: Thyroid nodules are the most common thyroid disease. In the majority of cases, they are benign. However, 5 to 15% of nodules are cancer. The aim of our study was to determine the clinical and biological predictive factors of malignancy in thyroid nodules.Methods: We performed a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital over 18 year old period (2000–2018). All the...

Background: Ultrasound is valuable for identifying many malignant or potentially malignant thyroid nodules. The aim of this study was to evaluate the efficacy of ultrasonographic (US) features in predicting the malignancy of thyroid nodules in a group of Tunisian patients.Methods: We conducted a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital. All these patients underwent thyroidectomy...

Introduction: The goiter represents the most common of all the disorders of the thyroid gland. Many Factors may be involved in the evolution of multinodular goiter. Although thyroid stimulating hormone (TSH) was described as the most important goitrogen factor, impairment of TRH-induced TSH release was reported with nodular goiter, suggesting thyroid autonomy. Herein, we report two cases of an isolated thyrotropin deficiency in patient presented with a voluminous goiter.<p...

Abnormal movements like hemichorea are rarely described as neurological manifestations of hyperglycemia. It is occur in nonketotic hyperglycemia with a pathognomonic radiological findings. We report a case of a 70 years old women with no past medical history who presented to the emergency department with abnormal limb movements. It was repetitive, brief, involuntary movement of the right arm evolving for 5 days. On admission, neurological examination showed right hemichorea. S...

Introduction: Hypothyroidism is not a common cause of renal failure which remains under-appreciated. Herein we report a case of acute renal failure in a patient with a severe primary hypothyroidism in whom hormone replacement therapy with Levothyroxine has significantly improved renal function.Observation: A 72-year-old man was referred to our department for primary hypothyroidism. His past medical history included a coronary heart disease with a heart f...

The risk of hypotension during Ramadan fasting in patients with adrenal insufficiency is unknown. The aim of our study was to evaluate objectively this risk.Methods: It is a prospective case-crossover study on 28 patients with known and treated AI. Patients had no hypertension and were regular fasters. All patients underwent a clinical examination and a 24-hours blood pressure monitoring during Ramadan fasting then outside fasting....

Introduction: Diabetic foot disease is a major health problem. The identification of its risk factors should guide preventive measures. The aim of this study was to determine the factors associated with diabetic foot complications.Patients and methods: It is a retrospective study including 47 patients admitted at the department of Endocrinology in La Rabta hospital for diabetic foot complications during the years 2015 and 2016. Clinical and para-clinical...

Background: Cardiothyreosis (CT) or thyrotoxic heart is associated with higher morbidity and mortality than the other forms of hyperthyroidism. Its risk factors have been investigated in a limited number of studies. The aim of our study was to identify risk factors of CT in patients with hyperthyroidism.Methods: We identified 538 patients with a hospital discharge diagnosis of hyperthyroidism from January 2000 to December 2015. Thirty five patients were ...

Subclinical hypothyroidism (SCH) is a common disorder and indications of treatment are still being debated. The aim of our study was to describe the therapeutic and evolutionary characteristics of SCH.Methods: We undertook a longitudinal retrospective study in 110 patients with SCH biologically defined by increased serum thyroid-stimulating hormone (TSH) levels (>4 mIU/l) and normal FT4. Pregnancy, age less than 18 years, personal history of partial ...

Introduction: The syndrome of resistance to thyroid hormone is a rare inherited disorder characterized by elevated circulating thyroid hormones, failure to suppress pituitary thyroid stimulating hormone (TSH) and variable tissue target hyposensitivity to thyroid hormone action. We reported the case of a RTH syndrome with a novel mutation.Case report: A 15-year-old girl was investigated for visual hallucinations and behavior disorders. Her medical history...